Research & Development
Discover CAR-T Therapy
Discover CAR-T Therapy
Discover CAR-T Therapy
The full name of CAR-T therapy is Chimeric Antigen Receptor (CAR) T-cell Therapy. The concept originated in 1989, and achieved its first clinical success in 2012 by curing a 7-year-old child with acute lymphoblastic leukemia. CAR-T therapy is currently one of the hottest and fastest-growing fields in the biopharmaceutical industry. Innovation and R&D activities are advancing rapidly. It has not only become a new hope for curing multiple types of cancer, but also holds tremendous potential for applications in autoimmune diseases, inflammatory disorders, degenerative diseases, and organ regeneration. The field is full of opportunities and vast space for innovation and entrepreneurship.
REVO-U
REVO-U is Wondercel’s proprietary universal CAR-T platform built on a fundamentally different principle: instead of cutting and rewriting T cell DNA, we leverage protein-level engineering to achieve GvHD prevention, immune resistance, and enhanced potency all without gene editing.
Technology Platform

Our Pipeline

Leveraging the REVO-U off-the-shelf CAR-T platform and iTreg technology to deliver transformative therapies across hematologic malignancies, solid tumors, autoimmune diseases, and organ transplantation.

9
Programs
Targets Disclosed
4
Therapeutic Areas
2
Platforms

Clinical & Preclinical Pipeline

REVO-U Allogeneic CAR-T
iTreg Platform
Planned
REVO-U Allogeneic CAR-T Platform
Gene-editing-free · Modular design · Scalable manufacturing (>3,000 doses/batch)
Product Target Indication Preclinical IIT Phase I Phase II
UWD-19 LEAD CD19
B-cell Lymphoma / Leukemia Multiple Autoimmune Diseases
UWD-19B DUAL
CD19 + BCMA
Multiple Myeloma Multiple Autoimmune Diseases
UWD-02 Undisclosed
Acute Myeloid Leukemia (AML)
UWD-01 Solid Tumor GUCY2C
Colorectal Cancer Gastric Cancer, Esophageal Cancer
UWD-03 Solid Tumor GPC3
Hepatocellular Carcinoma Lung Squamous Cell Carcinoma
UWD-04 Solid Tumor DLL3
Small Cell Lung Cancer
UWD-05 Solid Tumor Undisclosed
Pancreatic Cancer Ovarian / Lung / Head & Neck Cancer
UWD-06 Solid Tumor Undisclosed
Breast Cancer
iTreg Platform
Induced Regulatory T Cells · Immune Tolerance Engineering
Product Target Indication Preclinical IIT Phase I Phase II
WD-iT1 Transplant
Kidney Transplantation Liver / Lung Transplantation

REVO-U Platform: Gene-editing-free allogeneic CAR-T with modular architecture enabling multi-target expansion. Scalable manufacturing at >3,000 doses per batch.

iTreg Platform: Clinical data in 2 kidney transplant patients demonstrating reduced immunosuppressant usage. CAR-iTreg development underway with the goal of complete immunosuppressant withdrawal.

All programs are investigational. Pipeline stages reflect current development status and are subject to change.

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