

Research & Development
Discover CAR-T Therapy

Discover CAR-T Therapy
The full name of CAR-T therapy is Chimeric Antigen Receptor (CAR) T-cell Therapy. The concept originated in 1989, and achieved its first clinical success in 2012 by curing a 7-year-old child with acute lymphoblastic leukemia.
CAR-T therapy is currently one of the hottest and fastest-growing fields in the biopharmaceutical industry. Innovation and R&D activities are advancing rapidly. It has not only become a new hope for curing multiple types of cancer, but also holds tremendous potential for applications in autoimmune diseases, inflammatory disorders, degenerative diseases, and organ regeneration. The field is full of opportunities and vast space for innovation and entrepreneurship.
REVO-U
REVO-U is Wondercel’s proprietary universal CAR-T platform built on a fundamentally different principle: instead of cutting and rewriting T cell DNA, we leverage protein-level engineering to achieve GvHD prevention, immune resistance, and enhanced potency all without gene editing.
Technology Platform
Our Pipeline
Leveraging the REVO-U off-the-shelf CAR-T platform and iTreg technology to deliver transformative therapies across hematologic malignancies, solid tumors, autoimmune diseases, and organ transplantation.
9
Programs
5
Targets Disclosed
4
Therapeutic Areas
2
Platforms
Clinical & Preclinical Pipeline
REVO-U Allogeneic CAR-T
iTreg Platform
Planned
REVO-U Allogeneic CAR-T Platform
Gene-editing-free · Modular design · Scalable manufacturing (>3,000 doses/batch)
| Product | Target | Indication | Preclinical | IIT | Phase I | Phase II |
|---|---|---|---|---|---|---|
| UWD-19 LEAD | CD19 |
B-cell Lymphoma / Leukemia Multiple Autoimmune Diseases
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| UWD-19B DUAL |
CD19 + BCMA
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Multiple Myeloma Multiple Autoimmune Diseases
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| UWD-02 | Undisclosed |
Acute Myeloid Leukemia (AML)
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| UWD-01 Solid Tumor | GUCY2C |
Colorectal Cancer Gastric Cancer, Esophageal Cancer
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| UWD-03 Solid Tumor | GPC3 |
Hepatocellular Carcinoma Lung Squamous Cell Carcinoma
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| UWD-04 Solid Tumor | DLL3 |
Small Cell Lung Cancer
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| UWD-05 Solid Tumor | Undisclosed |
Pancreatic Cancer Ovarian / Lung / Head & Neck Cancer
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| UWD-06 Solid Tumor | Undisclosed |
Breast Cancer
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iTreg Platform
Induced Regulatory T Cells · Immune Tolerance Engineering
| Product | Target | Indication | Preclinical | IIT | Phase I | Phase II |
|---|---|---|---|---|---|---|
| WD-iT1 Transplant | — |
Kidney Transplantation Liver / Lung Transplantation
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REVO-U Platform: Gene-editing-free allogeneic CAR-T with modular architecture enabling multi-target expansion. Scalable manufacturing at >3,000 doses per batch.
iTreg Platform: Clinical data in 2 kidney transplant patients demonstrating reduced immunosuppressant usage. CAR-iTreg development underway with the goal of complete immunosuppressant withdrawal.
All programs are investigational. Pipeline stages reflect current development status and are subject to change.















